Organised by the Adriatic Ionian Euroregion, the second High-Level Conference on Circular Economy in the Adriatic Ionian Region discussed the uptake of circular principles in the context of multi-actor and multi-level governance. Key stakeholders of the Adriatic Ionian Macroregion such as the OECD, national-level governing structures supporting the EUSAIR, the EUSBSR and the EUSDR provided their inputs. Representatives of Western Balkan youth organisations presented their concrete actions to create awareness, facilitate community engagement in embracing circular economy and sustainability.